Aging in Cell and Tissue Culture: Proceedings of a symposium by E. Holeckova

By E. Holeckova

the yearly assembly of the eu Tissue tradition ., Society used to be held on the citadel of Zinkovy in Czechoslovakia from may well 7-10,1969. integrated as a part of this assembly was once a symposium on "Aging in cellphone and Tissue Culture." This quantity comprises the papers offered at that symposium. using mobile and tissue tradition strategies to review the mechanism of getting older isn't really new. for instance, it has lengthy been recognized that age-associated alterations which happen in plasma can inhibit mobile proliferation in vitro; additionally that the time lapse sooner than mobilephone migration from ex­ planted tissue fragments raises with expanding age. those are either examples of the expression in vitro of getting older in vivo. extra lately, awareness has been fascinated about the incidence of senescence in vitro. those investi­ gations have incorporated reports of adjustments in non­ dividing cellphone cultures, and to a slightly better volume, of age-related alterations within the proliferative potential of cells in vitro. for instance, cells derived from human fetal lung continue many houses of standard cells together with a good common diploid karyotype and those cultures were proven to have a constrained life-span in vitro. In addi­ tion, cultures derived from human grownup lung convey a similar general features and seem to have a shorter lifestyles­ span than cells derived from fetal lung.

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